All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. Monitoring of the primary outcomes from the trials will continue until August 2021, while monitoring of the secondary outcomes will continue until January 2023. Early morning anxiety and emergence of anxiety symptoms between doses of XANAX have been reported in patients with panic disorder taking prescribed maintenance doses. Unleashing the next wave of scientific innovations, Research and Business Development Partnerships. WebThe street value of Xanax varies depending on location and the dosage of the pill. Easy to order and reorder. WebThis product information is intended only for residents of the United States. Other common Xanax side effects include: Difficulty speaking Problems with coordination Xanax XR is used in the treatment of panic disorder and belongs to the drug class benzodiazepines . WebThe use of benzodiazepines, including XANAX, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death. Some patients may benefit from an even more gradual discontinuation. General disorders and administration site conditions: Edema peripheral, Hepatobiliary disorders: Hepatitis, hepatic failure, jaundice, Reproductive system and breast disorders: Gynecomastia, galactorrhea, menstruation irregular, Skin and subcutaneous tissue disorders: Photosensitivity reaction, angioedema, Stevens-Johnson syndrome. WebThe use of benzodiazepines, including XANAX, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death. Table 4 includes clinically significant drug interactions with XANAX XR [see Clinical Pharmacology (12.3)]. In panic disorders 0.5 mg 3 times a day, the daily dose can reach 3-6 mg, the highest daily dose 10 mg. (of a stimulus or mental process) below the threshold of sensation or consciousness; perceived by or affecting someones mind without their being aware of it. WebAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Manifestations of alprazolam overdosage include somnolence, confusion, impaired coordination, diminished reflexes, and coma. This informationincluding product informationis intended only for residents of the United States. The white, rectangle Xanax pill with the imprint X ANA X 2 supplied by Pfizer U.S. Pharmaceuticals Group is a very common brand of alprazolam containing 2mg of the active ingredient. Abuse and misuse of benzodiazepines often (but not always) involve the use of doses greater than the maximum recommended dosage and commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes, including respiratory depression, overdose, or death, To reduce the risk of withdrawal reactions, use a gradual taper to discontinue XANAX XR or reduce the dosage (a patient-specific plan should be used to taper the dose), The continued use of benzodiazepines, including XANAX XR, may lead to clinically significant physical dependence. Further increase in the dose (up to 0.5-0.75 mg / day) is carried out with caution for good tolerability of the drug. Dont increase your dosage of this medication without talking to your doctor, even if you think its not working. Table 3 shows the incidence of discontinuation-emergent adverse reactions that occurred during short-term, placebo-controlled trials in 5% or more of patients treated with XANAX XR where the incidence in patients treated with XANAX XR was 2 times greater than the incidence in placebo-treated patients. 4 yr. ago Damn, whats up with all the downvotes? (5.2) Abrupt discontinuation or rapid dosage reduction of XANAX after See 17 for PATIENT COUNSELING INFORMATION and Medication Guide. Use of XANAX XR during the later stages of pregnancy can result in sedation (respiratory depression, lethargy, hypotonia) and withdrawal symptoms (hyperreflexia, irritability, restlessness, tremors, inconsolable crying, and feeding difficulties) in the neonate. Call your doctor right away if you have any of these signs of an allergic reaction to Xanax xr : -Hives XANAX XR is indicated for the treatment of panic disorder with or without agoraphobia, in adults. Limit dosages and durations to the minimum required. The service is difficult to criticize. Even taking benzodiazepines as prescribed may put patients at risk for abuse and misuse of their medication. Advise patients not to drive or operate heavy machinery until the effects of concomitant use with the opioid have been determined [see Drug Interactions (7.1)]. The support staff is very helpful and polite. Insomnia Do not drive, operate heavy machinery, or do other dangerous activities until you know how XANAX XR affects you. Tolerance is a physiological state characterized by a reduced response to a drug after repeated administration (i.e., a higher dose of a drug is required to produce the same effect that was once obtained at a lower dose). Ritonavir: Interactions involving HIV protease inhibitors (eg, ritonavir) and alprazolam are complex and time dependent. Your healthcare provider will tell you how much XANAX XR to take and when to take it. XANAX XR may produce physical dependence from continued therapy. Doses are selected depending on the severity of the syndrome, the individual sensitivity of the patient and his reaction to the drug. Alprazolam is extensively metabolized in humans, primarily by cytochrome P450 3A4 (CYP3A4), to two major active metabolites in the plasma: 4-hydroxyalprazolam and -hydroxyalprazolam. WebThe U.S. WebWomen's Health. Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages (i.e., higher and/or more frequent doses) and those who have had longer durations of use [see Warnings and Precautions (5.3)]. Benzodiazepines are often sought by individuals who abuse drugs and other substances, and by individuals with addictive disorders [see Warnings and Precautions (5.2)]. McKesson Shop Products Shop by Category Pfizer #00009009001; Xanax Alprazolam 1 mg Tablet Bottle 100 Tablets CIV XANAX, TAB 1MG (100/BT) CIV. Thanks, Live Search Today, Excellent service & has all the products I need to purchase, always arrives on time. If your depression gets worse or you have suicidal thoughts, call your doctor right away. This may be caused by decreased clearance of alprazolam in patients with alcoholic liver disease. Physician Prescribing Information. Pill with imprint XANAX 2 is White Long Bar, Anxiety Disorders. 2. The following adverse reactions have been identified during post-approval use of XANAX and/or XANAX XR. Interactions involving ritonavir and alprazolam are complex and time dependent. Advise patients to inform their healthcare provider of all medicines they take, including prescription and nonprescription medications, vitamins and herbal supplements [see Drug Interactions (7)]. Thanks usamedzone.com The complete flumazenil package insert should be consulted prior to use. Its a type of benzodiazepine that is usually prescribed to people dealing with anxiety disorders. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. XANAX XR- alprazolamtablet, extended releasePharmacia & Upjohn Company LLC, XANAX XR is a benzodiazepine indicated for the treatment of panic disorder with or without agoraphobia, in adults. Pharmacists can take an active role in preventing counterfeit drugs by ensuring that they source products only from a reputable wholesaler or distributor. Xanax is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia). If the clinical response after switching is inadequate, titrate the dosage as outlined above. (, Neonatal Sedation and Withdrawal Syndrome (NOWS): Use of XANAX XR during pregnancy can result in neonatal sedation and neonatal withdrawal syndrome. Dispense in tight (USP), light-resistant, child-resistant containers. Preston Mcelheney CIV. Each XANAX XR extended-release tablet, for oral administration, contains 0.5 mg, 1 mg, 2 mg, or 3 mg of alprazolam. (, Patients with Depression: Exercise caution in patients with signs or symptoms of depression. Anxiety or tension caused by the stress of everyday life usually doesnt need to be treated with this drug. you are allergic to alprazolam, other benzodiazepines, or any of the ingredients in XANAX XR. The 2-mg dose of alprazolam in a Xanax bar is a heavy dose of the drug. Patients with alcoholic liver disease exhibit a longer elimination half-life (19.7 hours), compared to healthy subjects (11.4 hours). Pfizer was a component of the Dow Jones Industrial Average stock market index from 2004 to August 2020. Benzodiazepines cross the placenta and may produce respiratory depression and sedation in neonates. Other common Xanax side effects include: Difficulty speaking Problems with coordination Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages, and those who have had longer durations of use. Following is a list of other adverse reaction reported by 531 patients with panic disorder treated with XANAX XR. (5.2) Abrupt discontinuation or rapid dosage reduction of XANAX after As with the management of intentional overdosing with any drug, it should be borne in mind that multiple agents may have been ingested. Carbamazepine: The oral clearance of alprazolam (given in a 0.8 mg single dose) was increased from 0.900.21 mL/min/kg to 2.130.54 mL/min/kg and the elimination T1/2 was shortened (from 17.14.9 to 7.71.7 hour) following administration of 300 mg per day carbamazepine for 10 days [see Drug Interactions (7.2)]. In these studies, patients were treated with XANAX XR in a dose range of 1 mg to 10 mg once per day. a history of drug or alcohol addiction; or WebHigher dosage amounts (e.g. In patients already receiving an opioid analgesic, prescribe a lower initial dose of XANAX XR than indicated in the absence of an opioid and titrate based on clinical response. Fertility. The 2-mg dose of alprazolam in a Xanax bar is a heavy dose of the drug. Some of these can be life-threatening, such as seizures. It is composed of nucleoside-modified mRNA (modRNA) encoding a mutated form of the full-length spike protein of SARS-CoV-2, which is encapsulated in lipid nanoparticles. 1 BOTTLE 50 TABS, 2 BOTTLES 100 TABS, 4 BOTTLES 200 TABS, 6 BOTTLES 300 TABS, 8 BOTTLES 400 TABS, Your email address will not be published. Intravenous fluids should be administered and an adequate airway maintained. Adverse Reactions Occurring at an Incidence of 1% or More Among Patients Treated with XANAX XR. XANAX XR is a benzodiazepine and a CNS depressant with a potential for abuse and addiction. You and your healthcare provider should decide if you should take XANAX XR while you are pregnant. are breastfeeding or plan to breastfeed. Please visit Viatris.com for the most current product information. This drug belongs to a class of drugs called benzodiazepines. Pfizer. The vaccine is given by intramuscular injection. Your healthcare provider can tell you more about the differences between physical dependence and drug addiction. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. Although interactions between benzodiazepines and commonly employed clinical laboratory tests have occasionally been reported, there is no consistent pattern for a specific drug or specific test. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue XANAX XR or reduce the dosage [see Dosage and Administration (2.3), Warnings and Precautions (5.3)]. For its development BioNTech collaborated with Pfizer, an American company, for support with clinical trials, logistics, and manufacturing. The apparent volume of distribution of alprazolam is similar for XANAX XR and XANAX. Thanks usamedzone.com for pfizer xanax and for Delivering my pill. if you are allergic to alprazolam or to other benzodiazepines, such as chlordiazepoxide (Librium), clonazepam (Klonopin), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax). This drug attaches to certain benzodiazepine receptors in your brain and nervous system. How it works It has been identified that alprazolam 2 mg tablets in bottles of 50 marketed as Xanax have been supplied without child-resistant caps. It is dangerous to purchase Xanax on the Internet or from vendors outside the United States. XANAX XR is contraindicated with concomitant use of all strong CYP3A inhibitors, except ritonavir [see Contraindications (4), Warnings and Precautions (5.5), Drug Interactions (7.1)]. Both types of white Xanax pills are manufactured by Pfizer. XANAX XR U.S. Find out more about the street price of Klonopin (Clonazepam) Xanax (Alprazolam) Xanax is one of the most commonly abused benzodiazepines. The maximum recommended dosage is 4 mg daily (in divided doses). The chemical name of alprazolam is 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo [4,3-] [1,4] benzodiazepine. XANAX XR may harm your unborn baby. Panic disorder has been associated with primary and secondary major depressive disorders and increased reports of suicide among untreated patients. Ava is a digital health aid for womens health including cycle tracking, fertility, and pregnancy. Fluoxetine: Coadministration of fluoxetine with alprazolam increased the maximum plasma concentration of alprazolam by 46%, decreased clearance by 21%, increased T1/2 by 17%, and decreased measured psychomotor performance. (8.2). The elimination T1/2 was prolonged (30 hours versus 13 hours). Drug products that have been studied in vivo, along with their effect on increasing alprazolam AUC, are as follows: ketoconazole, 3.98 fold; itraconazole, 2.66 fold; nefazodone, 1.98 fold; fluvoxamine, 1.96 fold; and erythromycin, 1.61 fold [see Contraindications (4), Warnings and Precautions (5.5), Drug Interactions (7.2)]. For the same reason, patients should be cautioned about the concomitant use of alcohol and other CNS depressant drugs during treatment with XANAX XR [see Drug Interactions (7.1)]. Most side effects with Xanax xr happen when first starting the medication and these usually go away. What are the possible side effects of XANAX XR? Instruct patients that discontinuation or dosage reduction of XANAX XR may require a slow taper [see Warnings and Precautions (5.3), Drug Abuse and Dependence (9.3)]. Protect from light. Buy Medications in the Bulk Quantity fromusamedzone.com. But if you take several doses per day and miss a dose and its almost time for your next dose, skip the missed dose and continue your regular dosing schedule. The company ranks 64th on the Fortune 500 and 49th on the Forbes Global 2000. General supportive measures should be employed, along with immediate gastric lavage. The 2-mg dose of alprazolam in a Xanax bar is a heavy dose of the drug. XANAX XR is a registered trademark of Pharmacia & Upjohn Company LLC. Inactive ingredients: cellulose, corn starch, docusate sodium View Complete Details Get Latest Price Request a quote M/S Om Shree Navajeevan Medicines The mean dose of XANAX XR at the last treatment visit was 4.2 mg per day in the first study and 4.6 mg per day in the second. (1), Extended Release Tablets: 0.5 mg, 1 mg, 2 mg, and 3 mg (3), The most common adverse reactions in panic disorder patients treated with XANAX XR (incidence of 5% and at least twice that of placebo) include: somnolence, memory impairment, dysarthria, coordination abnormal, ataxia, libido decreased, constipation, and nausea. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue XANAX XR or reduce the dosage (a patient-specific plan should be used to taper the dose) [see Dosage and Administration (2.3)]. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. Alprazolam is in a class of medications called benzodiazepines. Safety and effectiveness of XANAX XR have not been established in pediatric patients. Protracted withdrawal symptoms may last weeks to more than 12 months. The PfizerBioNTech COVID-19 vaccine (tozinameran), sold under the brand name Comirnaty, is an mRNA-based COVID-19 vaccine developed by the German company BioNTech. Imipramine and Desipramine: The steady state plasma concentrations of imipramine and desipramine have been reported to be increased an average of 31% and 20%, respectively, by the concomitant administration of XANAX in doses up to 4 mg per day. WebAlprazolam 2mg Xanax Bars 2mg, Pfizer, 50"tab, Treatment: Anxiety,Antidepression 1,500/ Bottle Of 500 mL Get Latest Price Alprazolam is used to treat anxiety disorders and panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks). Acute withdrawal signs and symptoms associated with benzodiazepines have included abnormal involuntary movements, anxiety, blurred vision, depersonalization, depression, derealization, dizziness, fatigue, gastrointestinal adverse reactions (e.g., nausea, vomiting, diarrhea, weight loss, decreased appetite), headache, hyperacusis, hypertension, irritability, insomnia, memory impairment, muscle pain and stiffness, panic attacks, photophobia, restlessness, tachycardia, and tremor. If a patient develops withdrawal reactions, consider pausing the taper or increasing the dosage to the previous tapered dosage level. Reduce the dosage by no more than 0.5 mg every three days. Drugs demonstrated to be CYP3A inhibitors on the basis of clinical studies involving alprazolam: nefazodone, fluvoxamine, and cimetidine [see Drug Interaction (7.1), Clinical Pharmacology (12.3)]. In addition, fatalities have been reported in patients who have overdosed with a combination of a single benzodiazepine, including alprazolam, and alcohol; alcohol levels seen in some of these patients have been lower than those usually associated with alcohol-induced fatality. The pharmacokinetic parameters at steady-state for the two hydroxylated metabolites of alprazolam (4-hydroxyalprazolam and -hydroxyalprazolam) were similar for XANAX and XANAX XR, indicating that the metabolism of alprazolam is not affected by absorption rate. Alprazolam also comes as a solution. Its a type of benzodiazepine that is usually prescribed to people dealing with anxiety disorders. Because of the potential for serious adverse reactions, including sedation and withdrawal symptoms in breastfed neonates and infants, advise patients that breastfeeding is not recommended during treatment with XANAX XR. Alprazolam concentrations may be reduced by up to 50% in smokers compared to non-smokers. Xanax is a brand-name pill that contains alprazolam. XANAX XR is a benzodiazepine medicine. The risk of dependence is increased if you take higher doses or take this drug for a longer length of time. However, upon extended exposure to ritonavir (500 mg, twice daily for 10 days), CYP3A induction offset this inhibition. Its also available as a generic drug. WebA white Xanax bar contains 2 mg in one whole pill, but can easily be split into four different segments. The following adverse reactions have occurred with benzodiazepine abuse and/or misuse: abdominal pain, amnesia, anorexia, anxiety, aggression, ataxia, blurred vision, confusion, depression, disinhibition, disorientation, dizziness, euphoria, impaired concentration and memory, indigestion, irritability, muscle pain, slurred speech, tremors, and vertigo. Take the missed Xanax dose as soon as you remember. Alprazolam is 80% bound to human serum protein, and albumin accounts for the majority of the binding. Users who take Xanax report feeling the following effects: A calming sensation Feelings All forms are taken by mouth. This type of Xanax has XANAX clearly imprinted across the surface. An interim analysis of study data showed a potential efficacy of 91.3% in preventing infection within seven days of a second dose. Table 2 shows the incidence of adverse reactions that occurred during 6- and 8-week placebo-controlled trials in 1% or more of patients treated with XANAX XR where the incidence in patients treated with XANAX XR was greater than the incidence in placebo-treated patients. At this time, there is no clear evidence that alprazolam exposure in early pregnancy can cause major birth defects. Advise the patient to read the FDA-approved patient labeling (Medication Guide). -Impaired coordination Though Xanax does have legitimate medical uses, some people abuse it or take it recreationally. Increased digoxin concentrations have been reported when alprazolam was given, especially in geriatric patients (>65 years of age). Advise patients, their families and caregivers to look for signs of suicidality or worsening depression, and to inform the patient's healthcare provider immediately [see Warnings and Precautions (5.6)]. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Should any of the above events occur, alprazolam should be discontinued. WebXanax is the single most prescribed psychiatric drug in the United States; belongs to the benzodiazepines group of drugs. General disorders and administration site conditions: Reproductive system and breast disorders: Table 4: Clinically Significant Drug Interactions with XANAX XR, Strong Inhibitors of CYP3A (except ritonavir). Swallow XANAX XR tablets whole. There is positive evidence of human fetal risk during pregnancy. WebPfizer Xanax Packaging & Bottle. The following clinically significant adverse reactions are described elsewhere in the labeling: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Abuse is the intentional, non-therapeutic use of a drug, even once, for its desirable psychological or physiological effects. The most common events leading to discontinuation and considered to be drug-related (i.e., leading to discontinuation in at least 1% of the patients treated with XANAX XR at a rate at least twice that of placebo) are shown in Table 1. Also, dont stop taking this medication suddenly or decrease the dosage without talking to your doctor. The company has several blockbuster drugs or products that each generate more than US$1billion in annual revenues. Consequently, appropriate precautions (e.g., limiting the total prescription size and increased monitoring for suicidal ideation) should be considered in patients with depression. Compounds that are inhibitors or inducers of CYP3A would be expected to increase or decrease plasma alprazolam concentrations, respectively. Required fields are marked *. Xanax side effects Benzodiazepines cross the placenta and may produce respiratory depression and sedation in neonates. Caution is recommended during coadministration with alprazolam. Xanax is used in the treatment of anxiety; panic disorder; depression and belongs to the drug class benzodiazepines. WebXanax Alprazolam 1 mg Tablet Bottle 100 Tablets CIV Pfizer 00009009001. WebXANAX (alprazolam) This product information is intended only for residents of the United States. You can ask your pharmacist or healthcare provider for information about XANAX XR that is written for health professionals. 2 mg tablets) may be priced higher. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue XANAX XR or reduce the dosage. In a controlled postmarketing discontinuation study of panic disorder patients which compared the recommended taper schedule with a slower taper schedule, no difference was observed between the groups in the proportion of patients who tapered to zero dose; however, the slower schedule was associated with a reduction in symptoms associated with a withdrawal syndrome. Xanax alprazolam tablets, USP. A person who uses alprazolam regularly and has built up a tolerance to it, might feel euphoric or extremely mellow, but someone who is not used to the drug may become heavily sedated. asthma or other breathing disorder; WebXANAX XR (ALPRAZOLAM) 2MG PFIZER $150.00 $1,900.00 XANAX XR (ALPRAZOLAM) 2MG MAIN SUBSTANCE : Alpazolam CATEGORY : Benzo MANUFACTURER : Pfizer DOSAGE : 2-4 tabs/day PACKAGE : 2mg/tab 50 tabs Choose an Option Choose an option1 BOTTLE - 50 TABS2 BOTTLES - 100 TABS4 BOTTLES - 200 TABS6 BOTTLES - 300 TABS8 Depending upon the response, the dosage may be adjusted at intervals of every 3 to 4 days. No evidence of carcinogenic potential was observed in rats or mice administered alprazolam for 2 years at doses up to 30 and 10 mg/kg/day, respectively. Advise patients not to drive or operate heavy machinery until the effects of concomitant use with the opioid have been determined [see Warnings and Precautions (5.1), Drug Interactions (7.1)]. Do not drink alcohol or take other drugs that may make you sleepy or dizzy while taking XANAX XR without first talking to your healthcare provider. (, Limit dosages and durations to the minimum required. Generic drugs usually cost less. WebXANAX XR is a benzodiazepine indicated for the treatment of panic disorder with or without agoraphobia, in adults. Physician Prescribing Information. The products discussed herein may have different labeling in different countries. Episodes of hypomania and mania have been reported in association with the use of XANAX XR in patients with depression [see Adverse Reactions (6.1)]. Dispense in tight (USP), light-resistant, child-resistant containers. Anxiety Disorders The ability of alprazolam to induce human hepatic enzyme systems has not yet been determined. Clinical trials began in April 2020; by November 2020, the vaccine entered PhaseIII clinical trials, with over 40,000 people participating. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to XANAX XR during pregnancy. Do not share your XANAX XR with other people. In some cases, they may not be available in every strength or form as the brand-name version. Isolated published reports involving small numbers of patients have suggested that patients who have borderline personality disorder, a prior history of violent or aggressive behavior, or alcohol or substance abuse may be at risk for such events. Controlled trials of XANAX XR for the treatment of panic disorder included dosages in the range of 1 mg to 10 mg per day. Do not take more XANAX XR than prescribed or take XANAX XR for longer than prescribed. The U.S. Other brand names, as well as In addition, the 0.5 mg tablet contains FD&C Yellow No. Protracted withdrawal syndrome associated with benzodiazepines is characterized by anxiety, cognitive impairment, depression, insomnia, formication, motor symptoms (e.g., weakness, tremor, muscle twitches), paresthesia, and tinnitus that persists beyond 4 to 6 weeks after initial benzodiazepine withdrawal. In order to better understand the underground market for this drug, StreetRx collects data on the street price of Xanax and has found that its average black-market price is approximately $7. Inactive ingredients: cellulose, corn starch, docusate sodium View Complete Details Get Latest Price Request a quote M/S Om Shree Navajeevan Medicines Their half-lives appear to be similar to that of alprazolam. The extended-release drug is only used to treat panic disorder. buy the best quality steroids. Save my name, email, and website in this browser for the next time I comment. Instances of irritability, hostility, and intrusive thoughts have been reported during discontinuation of alprazolam in patients with posttraumatic stress disorder.
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